ADMINISTRATION ROUTES:
Transdermal
ALTERNATIVE NAMES:
Habitrol, Nicorette, Nicotrol
ICU INDICATIONS:
- Nicotine withdrawal
PRESENTATION AND ADMINISTRATION:
Transdermal:
Habitrol 14 mg/24 hours and 21 mg/24 hours
Apply to clean, dry, non-hairy skin on hip, chest or upper arm
Store at room temperature
DOSAGE:
Adjust dose for daily smoking habit:
< 20 cigarettes use 14 mg OD
≥ 20 cigarettes use 21 mg OD
DOSAGE IN RENAL FAILURE AND RENAL REPLACEMENT THERAPY:
Dose as in normal renal function
DOSAGE IN PAEDIATRICS:
Not applicable
CLINICAL PHARMACOLOGY:
Nicotine replacement therapy
CONTRAINDICATIONS:
- Active myocardial ischaemia
- Subarachnoid haemorrhage
- Recent cerebrovascular event
- Generalised dermatological disorders such as psoriasis or chronic dermatitis
WARNINGS:
Nicotine patches should be removed prior to undergoing an MRI. May cause arrhythmias
PRECAUTIONS:
General:
Nicotine patches should be used with caution in patients with:
- Severe hypertension, stable angina pectoris, cerebrovascular disease, occlusive peripheral arterial disease, or heart failure
- Hyperthyroidism or phaeochromocytoma
- Moderate to severe hepatic and/or severe renal impairment.
Laboratory Tests:
No tests in addition to usual ICU tests are indicated
Drug/Laboratory Test Interactions:
None of note
IMPORTANT DRUG INTERACTIONS IN ICU:
No clinically relevant interactions between nicotine replacement therapy and other drugs have definitely been established
ADVERSE REACTIONS:
Body as a Whole:
Headache, sweating, pallor
Skin reactions:
Skin reactions consisted of erythema or pruritus at the patch site. Oedema, burning sensation, blisters, rash, or pinching at the application site have also been noted
Gastrointestinal reactions:
Nausea, vomiting, dyspepsia, abdominal pain, diarrhoea
Neurological System:
Abnormal dreams