Wellington ICU Drug Manual: Appendices

appendix 5:
Antibiotic sensitivity overview

Wellington ICU Drug Manual - Antibiotic Spectra
  1. C. difficile should only be treated with metronidazole or vancomycin
  2. ESCHAPPM are β-lactamase producing organisms. These are Enterobacter, Serratia, Citrobacter freundii, Hafnia, Acinetobacter/Aeromonas, Proteus (not mirabilis), Providencia & Morganella morganii
  3. Not effective against Clostridium
  4. Metronidazole is not effective against Peptostreptococcus
  5. Teicoplanin is not effective against Enterococcus faecium
  6. Gentamicin is not appropriate mono therapy for Staphylococcus aureus & should only be used in conjunction with a β-lactam
  7. Due to increasing MIC, cefuxorime is not recommended therapy for Moraxella
  8. Although it has other actions, ceftazidime should only be used for Pseudomonas

For simplicity, atypical organisms are not included above. Partial columns indicate incomplete coverage.
ESBL-producing organisms are not susceptible to most antibiotics containing a beta-lactam ring; carbapenems are the usual agent of choice.

This chart does not replace local antibiotic preferences or ID expertise

Sources:

  • The Sanford Guide to Antimicrobial Therapy (2021)
  • Oh's Intensive Care Manual (2003)
  • Nelson's Pediatric Antimicrobial Therapy (2019)
  • MedSafe datasheets