SEARCH

Search any criteria by typing into the box above or browse from the links below.
Click on drug name or to access monograph.

Tablet $0.04

Doxazosin

Editor: Updated Class:

ADMINISTRATION ROUTES:

PO, NG

ALTERNATIVE NAMES:

Dosan, Apo-Doxazosin

ICU INDICATIONS:

  1. Hypertension refractory to other oral agents
  2. Patients may also be taking this medication at the time of ICU admission for benign prostatic hypertrophy (it is usually appropriate to withhold doxazosin given for this indication)

PRESENTATION AND ADMINISTRATION:

PO:

Apo-Doxazosin 2mg (white), Apo-Doxazosin 4mg (white), Dosan 4mg (white)

DOSAGE:

PO / NG:

Begin at 1 mg OD

Increase as required to max 16 mg daily

DOSAGE IN RENAL FAILURE AND RENAL REPLACEMENT THERAPY:

Dose as in normal renal function

DOSAGE IN PAEDIATRICS:

PO:

0.02 - 0.1 mg/kg daily

CLINICAL PHARMACOLOGY:

Doxazosin mesylate is a selective inhibitor of the alpha1-subtype of alpha adrenergic receptors

CONTRAINDICATIONS:

  1. Known hypersensitivity to doxazosin

WARNINGS:

First-Dose Effect:

Doxazosin, like other alpha-adrenergic blocking agents, can cause marked hypotension, particularly with the first dose

Priapism:

Doxazosin may cause priapism; if this occurs, urgent urological advice is required

PRECAUTIONS:

General:

Doxazosin should be administered with caution to patients with evidence of impaired hepatic function

Laboratory Tests:

No tests additional to routine ICU tests are required

Drug/Laboratory Test Interactions:

None known

IMPORTANT DRUG INTERACTIONS IN ICU:

Hypotension is more likely to occur when doxazosin is combined with other antihypertensives

ADVERSE REACTIONS:

Body as a Whole:

Malaise

Cardiovascular System:

Dizziness, hypotension

Skin & Appendages:

Rash

Central & Peripheral Nervous System:

Headache, paraesthesia, muscle cramps, somnolence

Gastrointestinal System:

Nausea, diarrhoea, constipation

Respiratory System:

Rhinitis