ADMINISTRATION ROUTES:
PO, NG, PR
ALTERNATIVE NAMES:
Aspec, Aspro, Cartia, Cardiprin, Disprin, Solprin
ICU INDICATIONS:
- Antiplatelet therapy for cardiovascular and cerebrovascular disease
PRESENTATION AND ADMINISTRATION:
PO:
Disprin 300 mg tablets (non-enteric coated) or Aspirin Ethics 100 mg (enteric coated).
PR:
300 mg suppository
Store at room temperature.
DOSAGE:
PO / NG:
For intubated patients:
150 mg once daily
Give as ½ of one 300 mg Disprin tablet crushed and administered via NG
For non-intubated patients who can swallow:
Aspirin Ethics EC 100 mg once daily
PR:
For intubated patients after cardiac surgery without an NG tube
150 mg PR
Prepare by cutting 300 mg suppository in half lengthways
DOSAGE IN RENAL FAILURE AND RENAL REPLACEMENT THERAPY:
Dose as in normal renal function
DOSAGE IN PAEDIATRICS:
PO:
Analgesia / antipyrexia:
10-15 mg/kg 4-6 hrly;
Kawasaki disease:
10 mg/kg 6hrly (low dose) OR 25 mg/kg 6 hrly (high dose) for 2 weeks then 3-5 mg/kg daily
CLINICAL PHARMACOLOGY:
Aspirin is a salicylate that has demonstrated antiplatelet, antiinflammatory, analgesic and antipyretic activity.
CONTRAINDICATIONS:
-
Hypersensitivity to aspirin
-
Gastrointestinal bleeding
WARNINGS:
Subclinical GI blood loss is common. Frank GI bleeding may occur
PRECAUTIONS:
General:
Aspirin tablets should be administered with caution to patients with asthma, nasal polyps, or nasal allergies.
Laboratory Tests:
No tests in addition to routine ICU tests are indicated
Drug/Laboratory Test Interactions:
Salicylates can produce changes in thyroid function tests
IMPORTANT DRUG INTERACTIONS IN ICU:
Oral hypoglycaemics:
Large doses of salicylates have a hypoglycaemic action and may enhance the effect of oral hypoglycaemics
Phenytoin:
Serum phenytoin levels may be increased by aspirin
Anticoagulants:
Combination with other anticoagulants increases the risk of bleeding
ADVERSE REACTIONS:
Body as a Whole:
Headache and fever, anaphylaxis
Digestive System:
Dyspepsia, thirst, nausea, vomiting, diarrhoea, acute reversible hepatotoxicity, gastrointestinal bleeding, and/or ulceration
Nervous System:
Mental confusion, drowsiness, and dizziness
Skin:
Urticaria, angioedema, and pruritus
Haematological System:
Prolongation of bleeding time, leukopaenia, thrombocytopaenia, purpura, decreased plasma iron concentration and shortened erythrocyte survival time
Special Senses:
Tinnitus, vertigo, reversible hearing loss, and dimness of vision