Note: this monograph does not apply to hyoscine hydrobromide (see next entry)
IV, PO, IM, SC
- Gastrointestinal tract spasm
PRESENTATION AND ADMINISTRATION:
20 mg in 1 mL (solution)
Room temperature. Protect from light.
Dilute required dose to 10 mL with Normal saline. Inject slowly over 3-5 minutes.
Compatible with the following IV fluids: Normal saline, 5% Glucose, Glucose and sodium chloride/
May be given into the side arm when the above IV fluids are being infused.
IM or SC:
Inject undiluted into a large muscle mass or subcutaneously
Buscopan 10 mg (white) Gastro-Soothe 10 mg (white)
IV, IM, SC, PO:
20-40 mg 6-8 hourly
DOSAGE IN RENAL FAILURE AND RENAL REPLACEMENT THERAPY:
Dose as in normal renal function
DOSAGE IN PAEDIATRICS:
0.5 mg/kg 6-8 hourly
Buscopan exerts a spasmolytic action on the smooth muscle of the gastrointestinal, biliary and urinary tracts. As a quaternary ammonium derivative, hyoscine-N-butylbromide does not enter the central nervous system so anticholinergic side effects at the central nervous system do not occur. Peripheral anticholinergic effects result from a ganglion-blocking action within the visceral wall as well as from anti- muscarinic activity.
- Myasthenia gravis
- Mechanical gastrointestinal tract obstruction
Hyoscine butylbromide may cause marked tachycardia
Hyoscine butylbromide may precipitate urinary retention
Hyoscine butylbromide should not be given by intramuscular injection to patients being treated with anticoagulant drugs as intramuscular haematomas may occur. In these patients, the subcutaneous or intravenous routes should be used
No tests in addition to routine ICU tests are required
Drug/Laboratory Test Interactions: None known
IMPORTANT DRUG INTERACTIONS IN ICU:
The anticholinergic effect of drugs such as tricyclic antidepressants, antihistamines, quinidine, amantadine, disopyramide and other anticholinergics (tiotropium, ipratropium) may be intensified by Hyoscine-N-butylbromide.
Concomitant treatment with dopamine antagonists such as metoclopramide may result in diminution of the effects of both drugs on the gastrointestinal tract.
The tachycardic effects of beta-adrenergic agents may be enhanced by Hyoscine-N-butylbromide.
Body as a Whole:
Anaphylactic shock, anaphylactoid reactions and other hypersensitivity, skin reactions
Tachycardia, hypotension, dizziness, flushing
Renal and urinary disorders: