ADMINISTRATION ROUTES:
PO
ALTERNATIVE NAMES:
Colgout
ICU INDICATIONS:
- Acute gout
PRESENTATION AND ADMINISTRATION:
PO:
Colgout 500 mcg tablets (white)
DOSAGE:
PO:
Acute Gout
1 mg then 500 mcg every 6 hours until pain relief achieved or diarrhoea occurs
Maximum 6 mg per course and 2500 mcg in 24 hours. Do not repeat course within 3 days.
DOSAGE IN RENAL FAILURE AND RENAL REPLACEMENT THERAPY:
Dose in renal impairment
GFR (ml/min) | DOSE |
---|---|
<10 | 50% of normal dose |
10-20 | 50% of normal dose |
>20-50 | 50% of normal dose |
Dose in renal replacement therapy
MODALITY | DOSE |
---|---|
CAPD | 50% of normal dose |
HD | 50% of normal dose |
CVVHDF | dose as in normal renal function |
DOSAGE IN PAEDIATRICS:
PO:
Acute Gout
0.02 mg/kg 2 hourly (maximum 3 doses per day)
Chronic Use
0.01-0.04 mg/kg daily
CLINICAL PHARMACOLOGY:
The mechanism of the relief afforded by colchicine in acute attacks of gouty arthritis is not completely known
CONTRAINDICATIONS:
- Diarrhoea
- Combined renal and hepatic impairment
WARNINGS:
Overdose can result in irreversible multiple organ failure and death
PRECAUTIONS:
General:
Reduction in dosage is indicated if weakness, anorexia, nausea, vomiting or diarrhoea occurs.
Laboratory Tests:
No tests in addition to routine ICU tests are indicated
Drug/Laboratory Test Interactions:
None noted
IMPORTANT DRUG INTERACTIONS IN ICU:
Colchicine has been shown to induce reversible malabsorption of vitamin B12, apparently by altering the function of ileal mucosa. The possibility that colchicine may increase response to central nervous system (CNS) depressants and to sympathomimetic agents is suggested by the results of experiments on animals
ADVERSE REACTIONS:
Central Nervous System:
Peripheral neuritis
Musculoskeletal System:
Muscular weakness
Gastrointestinal System:
Nausea, vomiting, abdominal pain or diarrhoea may be particularly troublesome in the presence of peptic ulcer or spastic colon
Haematological System:
Aplastic anaemia, agranulocytosis, or thrombocytopaenia
Skin:
Dermatitis, purpura, alopecia