ADMINISTRATION ROUTES:
PO, IM
ALTERNATIVE NAMES:
Codeine
ICU INDICATIONS:
- Relief of mild to moderate pain.
PRESENTATION AND ADMINISTRATION:
PO:
15mg and 30 mg tablets (white)
IM:
50 mg/1 mL vials. Inject undiluted via IM route. This route of administration is rarely used. NOT FOR IV USE
DOSAGE:
PO / IM:
15-60 mg q6hrly (to maximum 300 mg per day)
DOSAGE IN RENAL FAILURE AND RENAL REPLACEMENT THERAPY:
Dose in renal impairment
GFR (ml/min) | DOSE |
---|---|
<10 | 50-100% of normal dose |
10-20 | 75-100% of normal dose |
>20-50 | dose as in normal renal function |
Dose in renal replacement therapy
MODALITY | DOSE |
---|---|
CAPD | 50-100% of normal dose |
HD | 50-100% of normal dose |
CVVHDF | 75-100% of normal dose |
DOSAGE IN PAEDIATRICS:
PO:
0.5-1 mg/kg q4hrly
CLINICAL PHARMACOLOGY:
Codeine phosphate is a centrally active analgesic
CONTRAINDICATIONS:
- Hypersensitivity to codeine
WARNINGS:
Approximately 10% of Caucasian patients do not produce the enzyme required to convert codeine from its pro-drug form. These patients will derive no benefit from codeine
PRECAUTIONS:
General:
The respiratory depressant effects of narcotics and their capacity to depress consciousness may be markedly exaggerated in the presence of head injury, other intracranial lesions, or a pre-existing increase in intracranial pressure
Laboratory Tests:
No tests in addition to routine ICU tests are indicated
Drug/Laboratory Test Interactions:
None noted
IMPORTANT DRUG INTERACTIONS IN ICU:
Codeine in combination with other narcotic analgesics, general anaesthetics, phenothiazines, tranquilisers, sedative-hypnotics, or other CNS depressants (including alcohol) has additive depressant effects
ADVERSE REACTIONS:
Central Nervous System:
Lightheadedness, dizziness, sedation
Gastrointestinal System:
Constipation, nausea, vomiting