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Tablet $0.08

Codeine Phosphate

Editor: Updated Class:

ADMINISTRATION ROUTES:

PO, IM

ALTERNATIVE NAMES:

Codeine

ICU INDICATIONS:

  1. Relief of mild to moderate pain.

PRESENTATION AND ADMINISTRATION:

PO:

15mg and 30 mg tablets (white)

IM:

50 mg/1 mL vials. Inject undiluted via IM route. This route of administration is rarely used. NOT FOR IV USE

DOSAGE:

PO / IM:

15-60 mg q6hrly (to maximum 300 mg per day)

DOSAGE IN RENAL FAILURE AND RENAL REPLACEMENT THERAPY:

Dose in renal impairment

GFR (ml/min) DOSE
<10 50-100% of normal dose
10-20 75-100% of normal dose
>20-50 dose as in normal renal function

Dose in renal replacement therapy

MODALITY DOSE
CAPD 50-100% of normal dose
HD 50-100% of normal dose
CVVHDF 75-100% of normal dose

DOSAGE IN PAEDIATRICS:

PO:

0.5-1 mg/kg q4hrly

CLINICAL PHARMACOLOGY:

Codeine phosphate is a centrally active analgesic

CONTRAINDICATIONS:

  1. Hypersensitivity to codeine

WARNINGS:

Approximately 10% of Caucasian patients do not produce the enzyme required to convert codeine from its pro-drug form. These patients will derive no benefit from codeine

PRECAUTIONS:

General:

The respiratory depressant effects of narcotics and their capacity to depress consciousness may be markedly exaggerated in the presence of head injury, other intracranial lesions, or a pre-existing increase in intracranial pressure

Laboratory Tests:

No tests in addition to routine ICU tests are indicated

Drug/Laboratory Test Interactions:

None noted

IMPORTANT DRUG INTERACTIONS IN ICU:

Codeine in combination with other narcotic analgesics, general anaesthetics, phenothiazines, tranquilisers, sedative-hypnotics, or other CNS depressants (including alcohol) has additive depressant effects

ADVERSE REACTIONS:

Central Nervous System:

Lightheadedness, dizziness, sedation

Gastrointestinal System:

Constipation, nausea, vomiting