1 tablet

2 cents

Dosan, Apo-Doxazosin

  1. Hypertension refractory to other oral agents

  2. Patients may also be taking this medication at the time of ICU admission for benign prostatic hypertrophy (it is usually appropriate to withhold doxazosin given for this indication)

PO:
Apo-Doxazosin 2mg (white), Apo-Doxazosin 4mg (white), Dosan 4mg (white)


ADULT DOSE
PO / NG:
Commence with 1mg daily
Increase as required. Maximum 16mg daily

PAEDIATRIC DOSE
PO:
0.02-0.1mg/kg daily

DOSAGE IN RENAL FAILURE AND RENAL REPLACEMENT THERAPY
Dose as in normal renal function

Doxazosin mesylate is a selective inhibitor of the alpha1-subtype of alpha adrenergic receptors.

CONTRAINDICATIONS

  1. Known hypersensitivity to doxazosin


WARNINGS
First-Dose Effect
Doxazosin, like other alpha-adrenergic blocking agents, can cause marked hypotension, particularly with the first dose.
Priapism:
Doxazosin may cause priapism; if this occurs, urgent urological advice is required.

PRECAUTIONS
General:
Doxazosin should be administered with caution to patients with evidence of impaired hepatic function

Laboratory Tests:
No tests additional to routine ICU tests are required.

Drug/Laboratory Test Interactions:
None known.

Hypotension is more likely to occur when doxazosin is combined with other antihypertensives

Body as a Whole:
Malaise
Cardiovascular System
Dizziness, hypotension
Skin & Appendages
Rash
Central & Peripheral Nervous System
Headache, paraesthesia, muscle cramps, somnolence
Gastrointestinal System
Nausea, diarrhoea, constipation
Respiratory System
Rhinitis