1 vial

$100

IV:
Each 20ml vial contains 250mg of dobutamine
Add 250mg of dobutamine (20ml) to 80ml of compatible IV fluid (i.e. 250mg in 100ml)
Compatible with the following IV fluids:
Normal saline Glucose and sodium chloride 5% Dextrose
10% Dextrose Hartmanns
Store at room temperature
Protect from light


ADULT DOSE
IV:
Administered by infusion at rates of 2.5-20 mcg/kg/min

PAEDIATRIC DOSE
IV:
15mg/kg in 50ml of 5% dextrose or normal saline at 2.5-20mcg/kg/min (0.5-4ml/hr)
1ml/hr equals 5mcg/kg/min

DOSAGE IN RENAL FAILURE AND RENAL REPLACEMENT THERAPY
Dose as in normal renal function

Dobutamine is a direct-acting inotropic agent whose primary activity results from stimulation of the beta²-receptors of the heart while producing comparatively mild chronotropic, hypertensive, arrhythmogenic, and vasodilative effects.

CONTRAINDICATIONS

  1. Idiopathic hypertrophic subaortic stenosis

  2. Hypersensitivity to dobutamine


WARNINGS
Increase in Heart Rate or Blood Pressure:
Dobutamine may cause a marked increase in heart rate or blood pressure, especially systolic pressure.
Ectopic Activity:
Dobutamine may precipitate or exacerbate ventricular ectopic activity, but only rarely causes ventricular tachycardia.

Hypersensitivity:
Reactions suggestive of hypersensitivity associated with administration of dobutamine in 5% dextrose injection, including skin rash, fever, eosinophilia, and bronchospasm, have been reported occasionally.

PRECAUTIONS
General:
Hypovolemia should be corrected with suitable volume expanders before treatment with dobutamine

Laboratory Tests:
No tests additional to routine ICU tests are indicated

Drug/Laboratory Test Interactions:
None known.

Cardiovascular system:
Increased heart rate, hypotension, ventricular ectopy, atrial fibrillation, chest pain
Respiratory system:
Shortness of breath
Gastrointestinal system:
Nausea