1 tablet

10 cents

Imovane, Zimovane, Apo-Zopiclone
Zopiclone 7.5mg tablet

3.75-7.5mg nocte
0.1-0.4mg/kg nocte
Dose as in normal renal function
Zopiclone is a short-acting hypnotic with a pharmacological profile similar to that of the benzodiazepenes. It has hypnotic, sedative, anxiolytic, anti-convulsant & muscle-relaxant properties. It has negligible residual effects the following morning without rebound insomnia on cessation of treatment. It is rapidly & well absorbed after oral administration with an elimination half-life of 5 hours, prolonged to 7 hours in the elderly. It is not removed effectively by haemodialysis due to a large volume of distribution.
  • Hypersensitivity to Zopiclone

  • Myasthenia gravis

  • Severe sleep apnoea syndrome

  • Severe hepatic insufficiency

  • Respiratory failure

Risk of dependence if treatment duration is longer than 4 weeks; this is increased in patients with a history of drug abuse, alcoholism or personality disorders.

Risk of rebound & withdrawal after abrupt discontinuation after prolonged treatment. Gradual dose decrement is recommended, especially so in patients with a history of seizures

Anterograde amnesia may occur especially in the elderly or with disruption of sleep. This effect is dose-related. The risk of confusion is also higher in the elderly & in patients with cerebral impairment.

Additive effect with concomitant use of other central depressant drugs.

Laboratory Tests
No tests are required in addition to routine ICU blood tests

Drug/Laboratory Test Interactions
None known
Activity may be enhanced when co-administered with drugs that inhibit hepatic enzymes (particularly cytochrome P450) such as cimetidine or erythromycin
Nervous system:
Drowsiness, inco-ordination, headaches, fatigue
Arrhythmias (especially in elderly patients)
Dry mouth, heartburn, constipation, diarrhoea, nausea, vomiting
Urticaria, tingling
Thank you for your message. Someone will be in touch with you shortly.

Clinical responsibility for the choice, dose, route & frequency of any medication always remains with the prescribing doctor.
Content © 2014 Wellington ICU