1 tablet

10 cents

Imovane, Zimovane, Apo-Zopiclone
PO/NG:
Zopiclone 7.5mg tablet

3.75-7.5mg nocte
0.1-0.4mg/kg nocte
Dose as in normal renal function
Zopiclone is a short-acting hypnotic with a pharmacological profile similar to that of the benzodiazepenes. It has hypnotic, sedative, anxiolytic, anti-convulsant & muscle-relaxant properties. It has negligible residual effects the following morning without rebound insomnia on cessation of treatment. It is rapidly & well absorbed after oral administration with an elimination half-life of 5 hours, prolonged to 7 hours in the elderly. It is not removed effectively by haemodialysis due to a large volume of distribution.
CONTRAINDICATIONS:
  • Hypersensitivity to Zopiclone

  • Myasthenia gravis

  • Severe sleep apnoea syndrome

  • Severe hepatic insufficiency

  • Respiratory failure


WARNINGS
Risk of dependence if treatment duration is longer than 4 weeks; this is increased in patients with a history of drug abuse, alcoholism or personality disorders.

Risk of rebound & withdrawal after abrupt discontinuation after prolonged treatment. Gradual dose decrement is recommended, especially so in patients with a history of seizures

Anterograde amnesia may occur especially in the elderly or with disruption of sleep. This effect is dose-related. The risk of confusion is also higher in the elderly & in patients with cerebral impairment.



PRECAUTIONS
General
Additive effect with concomitant use of other central depressant drugs.

Laboratory Tests
No tests are required in addition to routine ICU blood tests

Drug/Laboratory Test Interactions
None known
Activity may be enhanced when co-administered with drugs that inhibit hepatic enzymes (particularly cytochrome P450) such as cimetidine or erythromycin
Nervous system:
Drowsiness, inco-ordination, headaches, fatigue
Cardiovascular:
Arrhythmias (especially in elderly patients)
Digestive:
Dry mouth, heartburn, constipation, diarrhoea, nausea, vomiting
Skin:
Urticaria, tingling
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Clinical responsibility for the choice, dose, route & frequency of any medication always remains with the prescribing doctor.
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