1 tablet

2 cents

Imodium, Nodia, Diamide

PO:
Tablets:
Imodium Caplets 2mg (light green)
Nodia 2mg tablets (green)
Capsules:
Diamide 2mg capsules (purple / dark green)
Imodium 2mg capsules (dark green / light grey)


ADULT DOSE

PO:
Initially 4mg, then 2mg after each unformed stool. Maximum 16mg/day.

PAEDIATRIC DOSE

PO:
0.05-0.1mg/kg 8-12 hourly; increase if required to 0.4mg/kg 8 hourly if required.

DOSAGE IN RENAL FAILURE AND RENAL REPLACEMENT THERAPY
Dose as in normal renal function

In vitro and animal studies show that loperamide acts by slowing intestinal motility and by affecting water and electrolyte movement through the bowel. Loperamide inhibits peristaltic activity by a direct effect on the circular and longitudinal muscles of the intestinal wall.

CONTRAINDICATIONS:

  • Pseudomembranous colitis or other infectious diarrhoea

  • Hypersensitivity to loperamide


WARNINGS
Loperamide therapy should be discontinued promptly if abdominal distention, constipation, or ileus occurs.

PRECAUTIONS
General
In acute diarrhoea, if clinical improvement is not observed in 48 hours, the administration of loperamide should be discontinued. Patients with hepatic dysfunction should be monitored closely for signs of CNS toxicity because of the apparent large first pass biotransformation. In patients with severe hepatic impairment, loperamide may cause CNS depression.

Laboratory Tests:
No tests are indicated in addition to routine ICU tests

Drug/Laboratory Test Interactions:
None known.

Body as a Whole:
Hypersensitivity reactions (including skin rash), tiredness, drowsiness or dizziness.
Gastrointestinal:
Abdominal pain, distention, or discomfort, nausea and vomiting, constipation, dry mouth.

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