1 vial 500mg

$76.00

  • Treatment of life threatening or sight threatening CMV infection

IV Use
Warning: Gancicolovir is a cytotoxic drug. Cytotoxic precautions apply.
Each vial contains 500mg of powder
Reconstitute each vial with 10ml of water for injection (giving a concentration of 50mg/ml). Shake well to dissolve powder. Add to 50-100ml of compatible IV fluid and administer over at least 1 hour.
Prepare immediately before use; reconstituted solution is stable at room temperature for 12 hours
Store at room temperature. Do not refrigerate.
Compatible with the following IV fluids:
Normal saline Hartmanns 5% glucose
Do not mix with other medications


ADULT DOSE

5mg/kg every 12 hours for 14 to 21 days followed by 5mg/kg daily

PAEDIATRIC DOSE

5mg/kg every 12 hours for 14 to 21 days followed by 5mg/kg daily

DOSAGE IN RENAL FAILURE AND RENAL REPLACEMENT THERAPY
Dose in renal impairment [GFR (ml/min)]
<10 1.25mg/kg 24 hourly
10-25 1.25mg/kg 24 hourly
25-50
2.5mg/kg 24 hourly
>50-69 2.5mg/kg 12 hourly

Dose in renal replacement therapy
CAPD 1.25mg/kg 24 hourly
HD 1.25mg/kg post dialysis
CVVHDF 2.5mg/kg 24 hourly

Ganciclovir is a synthetic guanine derivative active against cytomegalovirus (CMV

CONTRAINDICATIONS:

  • Hypersensitivity to ganciclovir, valganciclovir, acyclovir or valacyclovir


WARNINGS
Haematological
Ganciclovir should not be administered if the absolute neutrophil count is less than 500 or the platelet count is less than 25,000. Granulocytopaenia (neutropaenia), anaemia and thrombocytopaenia have been observed in patients treated with ganciclovir. The frequency and severity of these events vary widely in different patient populations.

PRECAUTIONS
General
See WARNINGS

Laboratory Tests
No tests are required in addition to routine ICU blood tests.

Drug/Laboratory Test Interactions
None reported

Since both zidovudine and ganciclovir have the potential to cause neutropaenia and anaemia, some patients may not tolerate concomitant therapy with these drugs at full dosage.
Generalized seizures have been reported in patients who received ganciclovir and imipenem-cilastatin. These drugs should not be used concomitantly; use meropenem instead of imipenem in this situation

Body as a Whole
Fever, Infection, Chills, Sepsis
Digestive System
Diarrhoea, anorexia, vomiting
Haematological System:
Leukopaenia, anaemia, thrombocytopaenia
Nervous System
Neuropathy
Other
Sweating, Pruritus

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