1 tablet

13 cents

Neurontin, Nupentin

  • Treatment of pain (particularly neuropathic pain)


Note: Gabapentin is an anticonvulsant but is not generally used for this indication in ICU

PO:
Capsules:
Neurontin 100mg capsules (white), Neurontin 300mg capsules (yellow), Neurontin 400mg capsules (orange)
Nupentin 100mg capsules (white), Nupentin 300mg capsules (yellow), Nupentin 400mg capsules (orange)

Tablets:
Neurontin 600mg tablets (white)


ADULT DOSE

PO / NG:
Commence with 100mg three times a day and increase as tolerated to a usual maximum of 1800mg per day (in divided doses); doses of up to 3600mg per day (in divided doses) have occasionally been used.

Note: Neurontin capsules can be opened and contents mixed with 10ml of water for administration via NG tube

PAEDIATRIC DOSE

PO:
2mg/kg three times daily; increase to 15mg/kg or higher if tolerated

DOSAGE IN RENAL FAILURE AND RENAL REPLACEMENT THERAPY
Dose in renal impairment [GFR (ml/min)]
<15 usual dose 300mg on alternate days
15-30 usual dose 300mg once daily
>30-60 usual dose 300mg twice daily
60-90 usual dose 400mg three times daily

Dose in renal replacement therapy
CAPD usual dose 300mg on alternate days
HD 200-300mg after each HD session
CVVHDF rarely indicated; increased doses may be required

Gabapentin is structurally related to the neurotransmitter GABA (gamma-aminobutyric acid). Its mechanism of action is unknown.

CONTRAINDICATIONS:

  • Hypersensitivity to gabapentin


WARNINGS
When gabapentin is used as an anticonvulsant, abrupt withdrawal may precipitate seizures

PRECAUTIONS
General
See WARNINGS

Laboratory Tests:
No tests in addition to routine ICU tests are required.

Drug/Laboratory Test Interactions
Because false positive readings were reported with the Ames N-Multistix SG dipstick test for urinary protein when gabapentin was added to other antiepileptic drugs, the more specific sulfosalicylic acid precipitation procedure is recommended to determine the presence of urine protein.

Body as a Whole
Headache, abdominal pain
Digestive System
Diarrhoea, dry mouth, constipation, nausea, vomiting, flatulence
Metabolic and Nutritional Disorders
Weight gain, Hyperglycaemia
Nervous System
Dizziness, Somnolence, Ataxia, Abnormal gait, Incoordination, Amnesia, Hypesthesia
Skin and Appendages
Rash

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