1 vial 100mcg

$1.22

1 vial 500mcg

$3.13

1 patch 100mcg/hr

$34.24

1 premix 1000mcg in 100ml bag

$23.17

Fentanyl, Durogesic, Sublimaze

  • Opioid analgesia

  • Induction of anaesthesia

IV:
100mcg in 2ml (50mcg/ml), 500mcg in 10ml (50mcg/ml)
500mcg in 50ml premixed syringes
Compatible with the following IV fluids:
Normal saline 5% glucose Glucose and Sodium Chloride
Store at room temperature
Use pre-mixed syringes for IV infusions; can be given either diluted or undiluted by IV push if required.

Transdermal:
12.5mcg/hour, 25mcg/hour, 50mcg/hour, 75mcg/hour, and 100mcg/hour patches
Apply to clean, dry, non hairy, non-irritated skin of the torso or upper arm.
Rotate application site.
Wear patch continuously for 72 hours.


ADULT DOSE

IV:
Infusion doses are typically 0-100mcg/hr
Doses as part of induction of anaesthesia are typically 50-200mcg in ICU patients; much higher doses are occasionally required.

Transdermal:
Usually commence with 25mcg/hour or less in the opioid naïve

PAEDIATRIC DOSE

IV:
1-10 mcg/kg; infusion 5-10 mcg/kg/hr
For infusion in paediatrics:
<10kg 100mcg/kg in 50ml 5% dextrose at 1-2ml/hr
>10kg 50mcg/ml at 0.04-0.08ml/kg/hr

DOSAGE IN RENAL FAILURE AND RENAL REPLACEMENT THERAPY
Dose in renal impairment [GFR (ml/min)]
<10 50% of normal dose
10-20 75% of normal dose
>20-50 dose as in normal renal function

Dose in renal replacement therapy
CAPD 50% of normal dose
HD 50% of normal dose
CVVHDF 75% of normal dose

Note: although these dosages provided here are indicative, fentanyl is titrated to effect and the required dose to achieve the desired effect is the correct dose (irrespective of the renal function)

Fentanyl citrate is a narcotic analgesic. A dose of 100 mcg is approximately equivalent in analgesic activity to 10 mg of morphine.

CONTRAINDICATIONS

  • Hypersensitivity to fentanyl


WARNINGS
May cause muscle rigidity, particularly involving the muscles of respiration, when given rapidly.

PRECAUTIONS
General:
Fentanyl may produce bradycardias

Laboratory Tests:
No tests additional to routine ICU tests are required

Drug/Laboratory Test Interactions:
None of note

Other CNS depressant drugs (e.g., barbiturates, tranquilizers, narcotics and general anaesthetics) will have additive or potentiating effects with fentanyl

Body as a Whole:
Anaphylaxis, pruritus, urticaria
Cardiovascular System:
hypertension, hypotension, and bradycardia
Respiratory System:
Laryngospasm, respiratory depression, and apnea
Gastrointestinal System:
Nausea, emesis,
Neurological System:
Dizziness, blurred vision, extrapyramidal symptoms (dystonia, akathisia and oculogyric crisis)

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