1 vial

$6.60

  • Drug-induced hypotension (particularly in association with bradycardia)

Note: used commonly in Anaesthesia but of limited utility in the ICU setting

IV:
Vial contains 30mg in 1ml
Dilute 30mg to a total of 10ml using normal saline (giving a concentration of 3mg/ml)
Store at room temperature
Protect from light
Compatible with the following IV fluids:
Normal saline 5% Dextrose 10% Dextrose Glucose and sodium chloride Hartmanns


ADULT DOSE

IV:
Administer by direct IV injection of 3-9mg (1-3ml) and repeat as required

PAEDIATRIC DOSE

IV:
0.25-1mg/kg (max 5mg/dose)

DOSAGE IN RENAL FAILURE AND RENAL REPLACEMENT THERAPY
Dose as in normal renal function

Ephedrine stimulates both alpha and beta receptors and its peripheral actions are due partly to norepinephrine release and partly to direct effect on receptors. Ephedrine may deplete norepinephrine stores in sympathetic nerve endings, so that tachyphylaxis to cardiac and pressor effects of the drug may develop.

CONTRAINDICATIONS

  • Hypersensitivity to ephedrine


WARNINGS
Ephedrine may cause hypertension resulting in intracranial haemorrhage. Ephedrine may induce anginal pain in patients with coronary insufficiency or ischaemic heart disease. The drug also may induce potentially fatal arrhythmias in patients with organic heart disease or who are receiving drugs that sensitise the myocardium


PRECAUTIONS
General:
Ephedrine should be used cautiously in patients with hyperthyroidism, hypertension, heart disease (including coronary insufficiency, angina pectoris and patients receiving digitalis), cardiac arrhythmias, diabetes or unstable vasomotor system.

Laboratory Tests:
No tests in addition to routine ICU tests are required.

Drug/Laboratory Test Interactions:
None known

Ephedrine should not be administered concomitantly with other sympathomimetic drugs because of possible additive effects and increased toxicity.
Alpha-adrenergic blocking agents may reduce the vasopressor response to ephedrine by causing vasodilation.
Beta-adrenergic blocking drugs may block the cardiac and bronchodilating effects of ephedrine.
Ephedrine also should be used cautiously with other drugs (e.g., digitalis glycosides) that sensitise the myocardium to the actions of sympathomimetic agents.

Cardiovascular system:
Hypertension, tachyarrhythmias, palpitations
Neurological system:
headache, restlessness, anxiety, tension, tremor, weakness, dizziness, confusion, delirium hallucinations
Gastrointestinal system:
nausea or vomiting

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