1 tablet

2 cents

Dosan, Apo-Doxazosin

  • Hypertension refractory to other oral agents

  • Patients may also be taking this medication at the time of ICU admission for benign prostatic hypertrophy (it is usually appropriate to withhold doxazosin given for this indication)

PO:
Apo-Doxazosin 2mg (white), Apo-Doxazosin 4mg (white), Dosan 4mg (white)


ADULT DOSE
PO / NG:
Commence with 1mg daily
Increase as required. Maximum 16mg daily

PAEDIATRIC DOSE
PO:
0.02-0.1mg/kg daily

DOSAGE IN RENAL FAILURE AND RENAL REPLACEMENT THERAPY
Dose as in normal renal function

Doxazosin mesylate is a selective inhibitor of the alpha1-subtype of alpha adrenergic receptors.

CONTRAINDICATIONS

  • Known hypersensitivity to doxazosin


WARNINGS
First-Dose Effect
Doxazosin, like other alpha-adrenergic blocking agents, can cause marked hypotension, particularly with the first dose.
Priapism:
Doxazosin may cause priapism; if this occurs, urgent urological advice is required.

PRECAUTIONS
General:
Doxazosin should be administered with caution to patients with evidence of impaired hepatic function

Laboratory Tests:
No tests additional to routine ICU tests are required.

Drug/Laboratory Test Interactions:
None known.

Hypotension is more likely to occur when doxazosin is combined with other antihypertensives

Body as a Whole:
Malaise
Cardiovascular System
Dizziness, hypotension
Skin & Appendages
Rash
Central & Peripheral Nervous System
Headache, paraesthesia, muscle cramps, somnolence
Gastrointestinal System
Nausea, diarrhoea, constipation
Respiratory System
Rhinitis

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