1 tablet

10 cents

PO:
Colgout 500mcg tablets (white)


ADULT DOSE
PO:
Acute Gout
1mg then 500mcg every 6 hours until pain relief achieved or diarrhoea occurs (maximum 6mg per course and 2500mcg/24 hours; do not repeat course within 3 days)

PAEDIATRIC DOSE
PO:
Acute Gout
0.02mg/kg 2 hourly (maximum 3 doses per day)
Chronic Use
0.01-0.04mg/kg daily

DOSAGE IN RENAL FAILURE AND RENAL REPLACEMENT THERAPY
Dose in renal impairment [GFR (ml/min)]
<10 50% of normal dose
10-20 50% of normal dose
>20-50 50% of normal dose

Dose in renal replacement therapy
CAPD 50% of normal dose
HD 50% of normal dose
CVVHDF Dose as in normal renal function

The mechanism of the relief afforded by colchicine in acute attacks of gouty arthritis is not completely known

CONTRAINDICATIONS:

  • Diarrhoea

  • Combined renal and hepatic impairment


WARNINGS
Overdose can result in irreversible multiple organ failure and death

PRECAUTIONS
General
Reduction in dosage is indicated if weakness, anorexia, nausea, vomiting or diarrhoea occurs.

Laboratory Tests:
No tests in addition to routine ICU tests are indicated

Drug/Laboratory Test Interactions:
None noted

Colchicine has been shown to induce reversible malabsorption of vitamin B12, apparently by altering the function of ileal mucosa. The possibility that colchicine may increase response to central nervous system (CNS) depressants and to sympathomimetic agents is suggested by the results of experiments on animals.

Central Nervous System:
Peripheral neuritis.
Musculoskeletal System:
Muscular weakness.
Gastrointestinal System:
Nausea, vomiting, abdominal pain or diarrhoea may be particularly troublesome in the presence of peptic ulcer or spastic colon.
Hematologic System:
Aplastic anaemia, agranulocytosis, or thrombocytopaenia.
Skin:
Dermatitis, purpura, alopecia.

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