1 tablet

5 cents

  • Relief of mild to moderate pain

PO:
15mg and 30mg tablets (white)

IM:
50mg/1ml vials. Inject undiluted via IM route
This route of administration is rarely used
NOT FOR IV USE


ADULT DOSE
PO / IM:
15-60mg 4 hourly (max 300mg per day

PAEDIATRIC DOSE
PO:
0.5-1mg/kg 4 hourl

DOSAGE IN RENAL FAILURE AND RENAL REPLACEMENT THERAPY
Dose in renal impairment [GFR (ml/min)]
<10 50-100% of normal dose
10-20 50-100% of normal dose
>20-50 Dose as in normal renal function

Dose in renal replacement therapy
CAPD 50-100% of normal dose
HD 50-100% of normal dose
CVVHDF 75-100% of normal dose

Codeine phosphate is a centrally active analgesic

CONTRAINDICATIONS:

  • Hypersensitivity to codeine.


WARNINGS
Approximately 10% of Caucasian patients do not produce the enzyme required to convert codeine from its pro-drug form. These patients will derive no benefit from codeine

PRECAUTIONS
General
The respiratory depressant effects of narcotics and their capacity to depress consciousness may be markedly exaggerated in the presence of head injury, other intracranial lesions, or a pre-existing increase in intracranial pressure.

Laboratory Tests:
No tests in addition to routine ICU tests are indicated

Drug/Laboratory Test Interactions:
None noted

Codeine in combination with other narcotic analgesics, general anaesthetics, phenothiazines, tranquilisers, sedative-hypnotics, or other CNS depressants (including alcohol) has additive depressant effects.

Central Nervous System:
lightheadedness, dizziness, sedation.
Gastrointestinal System:
Constipation, nausea, and vomiting.

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