1 tablet 10mg

61 cents

  • Secondary prevention in patients with coronary artery disease

  • Treatment of hypercholesterolaemia

PO / NG:
10mg, 20mg, 40mg and 80mg strengths (white). Tablets may be crushed for administration via NG tube.


ADULT DOSE
PO:
Commence at 10-20mg daily at night; slowly increase to a maximum of 80mg if required.

PAEDIATRIC DOSE
PO:
Familial hypercholesterolaemia:
0.2mg/kg daily, increased every 4 weeks to a maximum of 1.6mg/kg daily.

DOSAGE IN RENAL FAILURE AND RENAL REPLACEMENT THERAPY
Dose as in normal renal function

Atorvastatin is a selective, competitive inhibitor of HMG-CoA reductase. Atorvastatin is rapidly absorbed after oral administration; maximum plasma concentrations occur within 1-2 hours. It can be taken with or without food.

CONTRAINDICATIONS:

  • Active liver disease or unexplained persistent elevations of serum transaminases.

  • Hypersensitivity to any component of this medication.


WARNINGS
Liver Dysfunction
HMG-CoA reductase inhibitors, like some other lipid-lowering therapies, have been associated with biochemical abnormalities of liver function.
Skeletal Muscle
Rare cases of rhabdomyolysis with acute renal failure secondary to myoglobinuria have been reported with atorvastatin and with other drugs in this class.

PRECAUTIONS
General
Patients should be advised to report promptly unexplained muscle pain, tenderness, or weakness, particularly if accompanied by malaise or fever.

Laboratory Tests:
CK should be measured if there is concern about development of myopathy due to statins.

Drug/Laboratory Test Interactions
None known

The risk of myopathy during treatment with other drugs of this class is increased with concurrent administration of cyclosporin, fibric acid derivatives, niacin (nicotinic acid), erythromycin, and azole antifungals
When multiple doses of atorvastatin and digoxin were coadministered, steady-state plasma digoxin concentrations increased by approximately 20%. Patients taking digoxin should be monitored appropriately.

Body as a Whole:
Malaise
Digestive System:
Constipation, derangement of LFTs, flatulence, dyspepsia, and abdominal pain
Nervous System:
Insomnia, dizziness, paraesthesia, somnolence
Skin:
Pruritus
Musculoskeletal:
Myalgia, myopathy

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