Aspirin PO, NG
1 tablet 100mg EC
Aspec, Aspro, Cartia, Cardiprin, Disprin, Solprin
Antiplatelet therapy for cardiovascular and cerebrovascular disease
Disprin 300mg tablets (non-enteric coated) or Aspirin Ethics 100mg (enteric coated) .Store at room temperature.
For intubated patients use ½ a 300mg Disprin tablet daily crushed and administered via NG; for non-intubated patients use Aspirin Ethics 100mg (enteric coated) daily.
Analgesia / antipyrexia: 10-15mg/kg 4-6 hrly;
Kawasaki: 10mg/kg 6hrly (low dose) OR 25mg/kg 6hrly (high dose) for 2 weeks then 3-5mg/kg daily
DOSAGE IN RENAL FAILURE AND RENAL REPLACEMENT THERAPY
Dose as in normal renal function
Aspirin is a salicylate that has demonstrated antiplatelet, antiinflammatory, analgesic and antipyretic activity.
Hypersensitivity to aspirin.
Subclinical GI blood loss is common; frank GI bleeding may occur
Aspirin tablets should be administered with caution to patients with asthma, nasal polyps, or nasal allergies.
No tests in addition to routine ICU tests are indicated.
Drug/Laboratory Test Interactions
Salicylates can produce changes in thyroid function tests.
Large doses of salicylates have a hypoglycaemic action and may enhance the effect of the oral hypoglycaemics.
Serum phenytoin levels may be increased by aspirin.
Combination with other anticoagulants increases the risk of bleeding
Body as a Whole:
Headache and fever, anaphylaxis.
Dyspepsia, thirst, nausea, vomiting, diarrhoea, acute reversible hepatotoxicity, gastrointestinal bleeding, and/or ulceration.
Mental confusion, drowsiness, and dizziness
Urticaria, angioedema, and pruritus.
Prolongation of bleeding time, leukopaenia, thrombocytopaenia, purpura, decreased plasma iron concentration and shortened erythrocyte survival time.
Tinnitus, vertigo, reversible hearing loss, and dimness of vision.