1 tablet 100mg EC

4 cents

Aspec, Aspro, Cartia, Cardiprin, Disprin, Solprin

  • Antiplatelet therapy for cardiovascular and cerebrovascular disease

PO:
Disprin 300mg tablets (non-enteric coated) or Aspirin Ethics 100mg (enteric coated) .Store at room temperature.


ADULT DOSE
For intubated patients use ½ a 300mg Disprin tablet daily crushed and administered via NG; for non-intubated patients use Aspirin Ethics 100mg (enteric coated) daily.

PAEDIATRIC DOSE
PO
Analgesia / antipyrexia: 10-15mg/kg 4-6 hrly;
Kawasaki: 10mg/kg 6hrly (low dose) OR 25mg/kg 6hrly (high dose) for 2 weeks then 3-5mg/kg daily

DOSAGE IN RENAL FAILURE AND RENAL REPLACEMENT THERAPY
Dose as in normal renal function

Aspirin is a salicylate that has demonstrated antiplatelet, antiinflammatory, analgesic and antipyretic activity.

CONTRAINDICATIONS:

  • Hypersensitivity to aspirin.

  • Gastrointestinal bleeding.


WARNINGS
Subclinical GI blood loss is common; frank GI bleeding may occur

PRECAUTIONS
General
Aspirin tablets should be administered with caution to patients with asthma, nasal polyps, or nasal allergies.

Laboratory Tests:
No tests in addition to routine ICU tests are indicated.

Drug/Laboratory Test Interactions
Salicylates can produce changes in thyroid function tests.

Oral hypoglycaemics:
Large doses of salicylates have a hypoglycaemic action and may enhance the effect of the oral hypoglycaemics.
Phenytoin:
Serum phenytoin levels may be increased by aspirin.
Anticoagulants:
Combination with other anticoagulants increases the risk of bleeding

Body as a Whole:
Headache and fever, anaphylaxis.
Digestive System:
Dyspepsia, thirst, nausea, vomiting, diarrhoea, acute reversible hepatotoxicity, gastrointestinal bleeding, and/or ulceration.
Nervous System:
Mental confusion, drowsiness, and dizziness
Skin:
Urticaria, angioedema, and pruritus.
Haematological System:
Prolongation of bleeding time, leukopaenia, thrombocytopaenia, purpura, decreased plasma iron concentration and shortened erythrocyte survival time.
Special Senses:
Tinnitus, vertigo, reversible hearing loss, and dimness of vision.

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